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S.E.M.I.: Side Effects May Include...

SEMI.exe

2026Main GameReleasedThird person
Hack and slash/Beat 'em upIndieArcade

Summary:

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Storyline:

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Keywords:

Achievements:

Steam
9

External pages:

Links:

twohornunicorn.comx.comyoutube.comdiscord.gg

Media

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Details

Companies:

Two Horn Unicorn

Game modes:

Single player, Multiplayer, Co-operative

Themes:

Action, Comedy, Party

Game engines:

Unreal Engine 5

Languages:

Dutch, Chinese (Simplified), English, English (UK), Spanish (Spain), French, Japanese, Russian, Portuguese (Brazil), German

Age ratings:

ESRB: E10+, PEGI: 12, CERO: B, GRAC: 12+, USK: 12, CLASS_IND: 12, ACB: PG

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Release dates

Nov 20, 2025: Unknown platform (Worldwide)

Jan 23, 2026: Unknown platform (Worldwide)

Multiplayer

Online Co-op (up to 4)